Over a period of six months, this patient presented with symptoms related to arthritis, hematuria, oral ulceration, purpuric rash and occasional hematemesis. She remained untreated.
Some hours before death, she was hospitalized in a tertiary hospital. At that moment, serum creatinine level was found to be increased (6,9mg/dL). While on dialysis, she died after voluminous discharge of blood from the orotracheal tube.
At necropsy, purpuric rash on the upper and lower extremities was evident. Other findings included oral ulcerations, massive pulmonary hemorrhage (1050g, left lung; 1200g, right lung), pale kidneys and confluent serpiginous areas in the spleen (220g).
Under microscope, alveolar capillaritis and focal segmental necrotizing glomerulonephritis with crescent formation were observed. Necrosis and granulomatous vasculitis occurred in the spleen and palate. The purpuric lesions correspond to leukocytoclastic vasculitis.
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ABOUT THE EPONYM: FRIEDRICH WEGENER
From Wikipedia, the free encyclopedia
Friedrich Wegener (1907-1990) was a German pathologist who is notable for his description of a rare disease. Although this disease was known before Wegener's description, since the 1950s it has been called by the name Wegener’s granulomatosis.
Wegener joined the Nazi Party in 1932. As a relatively high ranking military doctor he spent some of the war in a medical office three blocks from the Lodz Ghetto, a Jewish ghetto in Lodz, Poland. There is speculation that he participated in experiments on concentration camp inmates.The American College of Chest Physicians (ACCP) awarded Wegener a “master clinician” prize in 1989. After his Nazi past was discovered in 2000, the ACCP rescinded the prize and, separately, a campaign was begun to rename Wegener’s granulomatosis to ANCA-associated granulomatous vasculitis.
Wegener joined the Nazi Party in 1932. As a relatively high ranking military doctor he spent some of the war in a medical office three blocks from the Lodz Ghetto, a Jewish ghetto in Lodz, Poland. There is speculation that he participated in experiments on concentration camp inmates.The American College of Chest Physicians (ACCP) awarded Wegener a “master clinician” prize in 1989. After his Nazi past was discovered in 2000, the ACCP rescinded the prize and, separately, a campaign was begun to rename Wegener’s granulomatosis to ANCA-associated granulomatous vasculitis.
READ MORE:
http://www.nytimes.com/2008/01/22/health/22dise.html
http://www.chestjournal.org/content/132/6/2065.full.pdf+html
http://www.chestjournal.org/content/132/6/2065.full.pdf+html
HEINRICH RUDOLF HERTZ AND WEGENER'S GRANULOMATOSIS 
The hertz standard unit was named in honor of Heinrich R. Hertz, a German physicist who was a pioneer in the study of electromagnetic radiation.
Heinrich Hertz is credited with the discovery of electromagnetic waves. Hertz performed numerous experiments and provided a wealth of data concerning reflection, refraction, and interference with regards to electric waves.
Heinrich Hertz died in 1892 of Wegener's granulomatosis at the age of 36.
Heinrich Hertz is credited with the discovery of electromagnetic waves. Hertz performed numerous experiments and provided a wealth of data concerning reflection, refraction, and interference with regards to electric waves.
Heinrich Hertz died in 1892 of Wegener's granulomatosis at the age of 36.
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